Fresh analysis reveals that people who stop using blockbuster slimming jabs like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who stop traditional diet and exercise plans.
Findings released in a major medical journal points out that while overweight individuals can lose a large proportion of their total mass while using the jabs, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"People buying such drugs need to be aware of the danger of fast weight regain when the medication concludes," cautioned expert Dr. Susan Jebb.
That rate of recovery suggests a reversion to starting mass in about one and a half years.
Comparing Therapies
The study, which reviewed dozens of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with older methods.
Researchers note that people who lose weight through lifestyle changes alone generally have a more gradual creep back—around 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Doctors propose the way of the jabs explains the accelerated regain.
These medications mimic a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Artificially providing GLP-1 concentrations several times higher than normal may cause the body to produce less of its own natural hormone, and could lessen responsiveness to its effects," noted Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication means appetite is unsuppressed, making binge eating much more probable."
A Lifelong Issue?
The NHS recommend the jabs for people with obesity-related health risks, alongside recommended diet and exercise modifications.
Professionals argue that, considering the significant potential of relapse, the therapy might need to be life-long.
This perspective is reinforced by drug manufacturers, who state that the findings "emphasize the persistent character of excess weight," akin to managing conditions like high blood pressure.
Patient Accounts
Individuals who have come off the medication describe a sudden resurgence of appetite.
"It felt as if something that goes on and you're instantly extremely hungry," said a patient.
The struggle is worsened if individuals have not established sustainable lifestyle or habit changes during treatment.
Growing Use
Figures show that millions of adults in the UK have used weight-loss jabs in the past year, with interest continuing to grow.
- Use is higher among females compared to men.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion obtain the drugs through private healthcare rather than public health services.
In conclusion, clinicians emphasize that while GLP-1 drugs are effective agents for shedding pounds, they are not a permanent solution and lasting health benefits hinges on combined lifestyle management.
